Article 3222

Title of the article

Paroxysms of atrial fibrillation and stages of the reproductive system aging in women 

Authors

Ruslan F. Rakhmatullov, Candidate of medical sciences, associate professor of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: pgu-vb2004@mail.ru
Fagim K. Rakhmatullov, Doctor of medical sciences, professor, head of the sub-department of internal diseases, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: pgu-vb2004@mail.ru 

Abstract

Backround. The study of the atrial fibrillation (AF) dependence on the activity of the hypothalamic-pituitary-reproductive system in women has important theoretical and practical significance. Recent studies have reflected data on the close relationship of AF with age-related aging. Most authors consider it necessary to study noninvasive methods to assess the conductive structures of the heart and to select rational schemes of recurrent therapy in this category of patients. The task of present work is to develop adequate methods for assessment of the cardiac conduction system and rational pharmacotherapy schemes for treatment of atrial fibrillation at the stages of reproductive aging of women using noninvasive methods of heart research. Material and methods. 184 women with paroxysms of AF (PAF) were examined, and divided into 3 groups. The 1st group includes 128 patients when PAF occurred at the postmenopausal period. The 2nd group includes 34 women who have PAF at the stage of transition to menopause. The 3rd group includes 22 women who have PAF in the reproductive period. Clinical and instrumental research methods include transesophageal electrocardiostimulation (TECS), Holters' monitoring of an electrocardiogram (ECG) and echocardiography (EchoCG). Results. It has found that in women, sensitivity of transesophageal stimulation of the heart in inducing PAF in the 1st group is 89.1%, in the 2nd - 73.5% and in the 3rd – 18.2%; the predictive value of a positive result are 98.3, 92.6 and 66.7%, and a negative result are 27.7, 49.1 and 51.9%, respectively; the specificity of the method is 93.3%. It has been shown that the first-line drugs for the prevention of PAF in women are cordarone and propanorm. It was revealed that in the combined therapy of PAF in women, the first stage is a combination of class I antiarrhythmic drugs with sotalol, the second stage is with cordarone. Conclusions. The data shows high informative of electrophysiological studies in the diagnosis and selection of therapy for atrial fibrillation in women. 

Key word

atrial fibrillation, electrophysiological examination of the heart, echocardiography, antiarrhythmic therapy 

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For citation:

Rakhmatullov R. F., Rakhmatullov F. K. Paroxysms of atrial fibrillation and stages of the reproductive system aging in women. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2022;(2):26–34. (In Russ.). doi:10.21685/2072-3032-2022-2-3

 

Дата создания: 22.06.2022 08:36
Дата обновления: 22.06.2022 08:50